Seven people suffered injuries early Sunday after one car caught fire and a dozen others, including an ambulance, wrecked in the fog on the Interstate 10 bridge over the Pascagoula River.
The pileup caused major traffic delays.
Mississippi Highway Patrol Sgt. Joe Gazzo said the 13-vehicle pileup began at 6 a.m. after an eastbound vehicle hit the bridge's wall, veering into an adjacent lane and hitting another vehicle before coming to rest sideways in the middle of the interstate.
The car caught fire, Gazzo said, after a third vehicle slammed into it. No life-threatening injuries were reported, though seven people were taken to area hospitals for treatment.
"It was very foggy," Gazzo said. "They couldn't see the traffic in time to stop."
As vehicles stopped for the initial wreck in the passing lane, another vehicle slammed into the back of them, causing a chain reaction.
An Acadian Ambulance responding to the scene also was hit, Gazzo said, just as it arrived at the scene.
"They had just pulled up," he said. "The two paramedics were still in the vehicle."
Acadian officials reached Sunday did not wish to comment.
Authorities reported eastbound traffic delays on I-10 for up to three hours, as authorities rerouted traffic along Mississippi 57, from Gautier to Moss Point.
Authorities did not identify the accident victims Sunday, though Gazzo said no one had suffered substantial injuries. Thirteen vehicles were towed from the scene, he said.
Gautier and Moss Point police officers and a Jackson County sheriff's deputy also responded to the scene to assist.
Other law enforcement agencies in South Mississippi responded to accidents Sunday, though no serious injuries were reported.