The crash happened around 4 p.m. on a winding road near the Luhi Summer Camp. The bus crashed, apparently head-on, with a blue Chevrolet Camaro about 20 miles east of New York City, officials said.
All 12 people on the bus were injured, but most of the injuries were minor, said Brian Carey, director of summer programs at the camp, which is connected to the Lutheran Church of Our Savior in Port Washington.
Two of the seriously injured people were riding in the car and one was a child on the bus, Nassau County fire officials said.
Carey said the 11 children hurt ranged in age from 7 to 14. The bus driver was taken to a hospital with chest pains, Carey said.
The injured were taken to Nassau University Medical Center in East Meadow and North Shore University Hospital in Syosset.
The medical center was treating two patients in critical condition, spokeswoman Shelley Lotenberg said. The others at the center suffered only minor injuries, she said.
A spokesman for the university hospital said he could not immediately comment.