Television footage showed emergency crews treating at least three people. Grayson County Sheriff's Sgt. Pam McCurdy said that she didn't know how many people were injured, but knew that some of the injuries were severe. A medical helicopter was dispatched.
Joe Faust, a spokesman for Burlington Northern Santa Fe Corp., said both of the trains belonged to the company.
The northbound and southbound trains collided head-on, and at least one of the locomotives burned.
Neither Faust nor McCurdy knew what caused the accident.
McCurdy said one of the trains derailed after the head-on collision. Television footage showed about 20 cars off the tracks.
The accident occurred in a rural area about 50 miles north of Dallas. No evacuations were immediately reported.